rasagiline   

GtoPdb Ligand ID: 6641

Synonyms: Azilect® | TVP-1012
rasagiline is an approved drug (EMA (2005), FDA (2006))
Compound class: Synthetic organic
Comment: Marketed formulations may contain rasagiline mesylate (PubChem CID 3052775).
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2D Structure
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Physico-chemical Properties
Hydrogen bond acceptors 1
Hydrogen bond donors 1
Rotatable bonds 2
Topological polar surface area 12.03
Molecular weight 171.1
XLogP 2.11
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
Canonical SMILES C#CCNC1CCc2c1cccc2
Isomeric SMILES C#CCN[C@@H]1CCc2c1cccc2
InChI InChI=1S/C12H13N/c1-2-9-13-12-8-7-10-5-3-4-6-11(10)12/h1,3-6,12-13H,7-9H2/t12-/m1/s1
InChI Key RUOKEQAAGRXIBM-GFCCVEGCSA-N
No information available.
Summary of Clinical Use
Used as an initial monotherapy in the early stages of Parkinson's disease and as an adjunctive to levodopa in the later stages of the disease.
Mechanism Of Action and Pharmacodynamic Effects
The exact mechanism of action of rasagiline is unknown, but is believed to relate to its inhibition of MAO-B leading to an increase in extracellular levels of dopamine in the striatum.
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