Ligand id: 6693

Name: galantamine

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Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 1
Rotatable bonds 1
Topological polar surface area 41.93
Molecular weight 287.15
XLogP 1.57
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Galantamine can improve and stabilize cognitive performance with efficacy and tolerability comparable to other cholinesterase inhibitors (rivastigmine and donepezil) for mild to moderate Alzheimers disease and other neurodegenerative disorders [3].
Mechanism Of Action and Pharmacodynamic Effects
Galantamine is a weak acetylcholinesterase inhibitor but has additional allosteric potentiating effects at nicotinic receptors and affects not only cholinergic transmission but also other neurotransmitter systems such as monoamines, glutamate, and GABA [1] .