drotrecogin alfa   Click here for help

GtoPdb Ligand ID: 6788

Synonyms: drotrecogin alfa (activated) | HSDB 7366 | Xigris®
Approved drug
drotrecogin alfa is an approved drug (FDA (2001), EMA (2009))
Comment: Drotrecogin alfa (activated) is a recombinant form of human activated protein C.
No information available.
Summary of Clinical Use Click here for help
In the USA drotrecogin was FDA approved for the reduction of mortality in adult patients with severe sepsis, but was withdrawn (2011) due to a failure to show a survival benefit for patients with severe sepsis and septic shock
Mechanism Of Action and Pharmacodynamic Effects Click here for help
Endogenous activated protein C exerts its antithrombotic effect by inhibiting blood coagulation factors Va and VIIIa. Drotrecogin alfa (activated) acts in the same way to produce its anti-thrombotic, anti-inflammatory, and profibrinolytic properties.