ethoxzolamide   Click here for help

GtoPdb Ligand ID: 6814

Synonyms: Cardrase® | Ethamide® | ethoxazolamide | ethoxyzolamide
Approved drug PDB Ligand
ethoxzolamide is an approved drug
Compound class: Synthetic organic
Comment: Carbonic anhydrase inhibitor
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 3
Topological polar surface area 118.9
Molecular weight 258.01
XLogP 0.36
No. Lipinski's rules broken 0
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Canonical SMILES CCOc1ccc2c(c1)sc(n2)S(=O)(=O)N
Isomeric SMILES CCOc1ccc2c(c1)sc(n2)S(=O)(=O)N
InChI InChI=1S/C9H10N2O3S2/c1-2-14-6-3-4-7-8(5-6)15-9(11-7)16(10,12)13/h3-5H,2H2,1H3,(H2,10,12,13)
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Summary of Clinical Use Click here for help
Used as a diuretic and to treat glaucoma and duodenal ulcers. There is no information regarding approval for clinical use of this drug on the US FDA or European Medicines Agency websites. Individual national approval agencies may have granted marketing authorisation.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
Carbonic anhydrase inhibition in the proximal tubules of the kidney underlies the drug's diuretic action, whereas inhibition of carbonic anhydrase in the eye reduces aqueous humor and relieves intraocular hypertension of glaucoma. The drug is believed to inhibit mainly carbonic anhydrase 1.