Ligand id: 6844

Name: teriflunomide

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 2
Rotatable bonds 4
Topological polar surface area 73.12
Molecular weight 270.06
XLogP 2.46
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used to reduce flare-ups in patients with relapsing multiple sclerosis (MS).
Mechanism Of Action and Pharmacodynamic Effects
This is the active metabolite of leflunomide. Teriflunomide is an immunomodulatory agent that acts by inhibiting pyrimidine synthesis. A reduction in pyrimidine levels has antiproliferative and anti-inflammatory effects on T cells.
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