hydromorphone   Click here for help

GtoPdb Ligand ID: 7082

Synonyms: Dilaudid® | hydromorphone hydrochloride | Palladone®
Approved drug
hydromorphone is an approved drug (FDA (1984))
Comment: Hydromorphone is an opioid receptor agonist.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 2
Hydrogen bond donors 1
Rotatable bonds 0
Topological polar surface area 49.77
Molecular weight 285.14
XLogP 0.6
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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Canonical SMILES O=C1CCC2C34C1Oc1c4c(CC2N(CC3)C)ccc1O
Isomeric SMILES O=C1CC[C@@H]2[C@@]34[C@H]1Oc1c4c(C[C@H]2N(CC3)C)ccc1O
InChI InChI=1S/C17H19NO3/c1-18-7-6-17-10-3-5-13(20)16(17)21-15-12(19)4-2-9(14(15)17)8-11(10)18/h2,4,10-11,16,19H,3,5-8H2,1H3/t10-,11+,16-,17-/m0/s1
InChI Key WVLOADHCBXTIJK-YNHQPCIGSA-N
No information available.
Summary of Clinical Use Click here for help
Used to treat moderate to severe pain.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
Agonist activity primarily at the μ opioid receptor in the central nervous system (CNS) causes hyperpolarization and reduced neuronal excitability by various mechanisms. See the DrugBank link for further details.
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