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Synonyms: Neo-Rx® | neomycin sulfate
neomycin is an approved drug (FDA (1964))
Compound class: Natural product or derivative
Comment: Neomycin is an aminoglycoside antibacterial. Neomycin is active against Gram-negative bacteria, and partially active against Gram-positive bacteria. Standard grade neomycin is a mixture of several related compounds, including neomycin A (neamine), neomycin B (framycetin) and neomycin C, with neomycin B being the most active component. We show the structure of neomycin B here.
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
|No information available.
|Summary of Clinical Use
|Used topically in the treatment of eye infections, otitis externa, treatment or prevention of bacterial infections in skin lesions and in the prevention of bacteriuria and gram negative rod bacteremia in abacteriuric patients with indwelling catheters. Also used orally to treat hepatic encephalopathy.
|Mechanism Of Action and Pharmacodynamic Effects
|Neomycin binds to 30S-subunit proteins and 16S rRNA. This leads to misreading of mRNA which in turn leads to the insertion of incorrect amino acids into the polypeptide which leads to the formation of nonfunctional or toxic peptides and breakup of polysomes into nonfunctional monosomes.
For extended ADME data see the following: