alprazolam   Click here for help

GtoPdb Ligand ID: 7111

Synonyms: Niravam® | U-31889 | Xanax®
Approved drug PDB Ligand
alprazolam is an approved drug (FDA (1981))
Compound class: Synthetic organic
Comment: Alprazolam is a benzodiazepine drug.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 3
Hydrogen bond donors 0
Rotatable bonds 1
Topological polar surface area 42.55
Molecular weight 308.08
XLogP 5.5
No. Lipinski's rules broken 1
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Canonical SMILES Clc1ccc2c(c1)C(=NCc1n2c(C)nn1)c1ccccc1
Isomeric SMILES Clc1ccc2c(c1)C(=NCc1n2c(C)nn1)c1ccccc1
InChI InChI=1S/C17H13ClN4/c1-11-20-21-16-10-19-17(12-5-3-2-4-6-12)14-9-13(18)7-8-15(14)22(11)16/h2-9H,10H2,1H3
No information available.
Summary of Clinical Use Click here for help
Used as an anxiolytic to treat generalised anxiety disorder (GAD), panic disorder and alcohol withdrawal.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
Alprazolam positively modulates the activity of GABAA anion channels. The drug increases inhibitory GABAergic tone and causes neuro-inhibition. Drug-induced effects are observed clinically as anxiolytic, sedative, anticonvulsant and skeletal muscle relaxant actions.
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