biperiden   Click here for help

GtoPdb Ligand ID: 7128

Synonyms: Akineton® | biperiden HCl | biperiden lactate
Approved drug
biperiden is an approved drug (FDA (1959))
Compound class: Synthetic organic
Comment: Biperiden is a centrally active anticholinergic drug.
Click here for help
2D Structure
Click here for help
Click here for structure editor
Physico-chemical Properties
Click here for help
Hydrogen bond acceptors 2
Hydrogen bond donors 1
Rotatable bonds 5
Topological polar surface area 23.47
Molecular weight 311.22
XLogP 4.1
No. Lipinski's rules broken 0
Click here for help
Canonical SMILES OC(C1CC2CC1C=C2)(c1ccccc1)CCN1CCCCC1
Isomeric SMILES OC(C1CC2CC1C=C2)(c1ccccc1)CCN1CCCCC1
InChI InChI=1S/C21H29NO/c23-21(19-7-3-1-4-8-19,11-14-22-12-5-2-6-13-22)20-16-17-9-10-18(20)15-17/h1,3-4,7-10,17-18,20,23H,2,5-6,11-16H2
No information available.
Summary of Clinical Use Click here for help
Used to relieve muscle rigidity, sweating, salivation, and improves gait and tremor in patients with parkinsonian syndrome.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
By antagonising the muscarinic acetylcholine M1 receptor, biperiden is believed to correct the imbalance between the excitatory (cholinergic) and inhibitory (dopaminergic) systems in the corpus striatum associated with Parkinsonism.
External links Click here for help