diphenylpyraline   

GtoPdb Ligand ID: 7165

Synonyms: Hispril®
diphenylpyraline is an approved drug
Compound class: Synthetic organic
Comment: Diphenylpyraline is a first-generation diphenylpiperidine antihistamine with anticholinergic effects.
2D Structure
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Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 0
Rotatable bonds 4
Topological polar surface area 12.47
Molecular weight 281.18
XLogP 3.7
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
Canonical SMILES CN1CCC(CC1)OC(c1ccccc1)c1ccccc1
Isomeric SMILES CN1CCC(CC1)OC(c1ccccc1)c1ccccc1
InChI InChI=1S/C19H23NO/c1-20-14-12-18(13-15-20)21-19(16-8-4-2-5-9-16)17-10-6-3-7-11-17/h2-11,18-19H,12-15H2,1H3
InChI Key OWQUZNMMYNAXSL-UHFFFAOYSA-N
No information available.
Summary of Clinical Use
Diphenylpyraline is an antihistamine used to treat allergic rhinitis, hay fever, and allergic skin disorders. There is no information regarding approval for clinical use of this drug on the US FDA website. Other national approval agencies may have granted marketing authorisation.
Mechanism Of Action and Pharmacodynamic Effects
Diphenylpyraline blocks the action of endogenous histamine at the histamine H1 receptor.