diphenylpyraline   

GtoPdb Ligand ID: 7165

Synonyms: Hispril®
diphenylpyraline is an approved drug
Compound class: Synthetic organic
Comment: Diphenylpyraline is a first-generation diphenylpiperidine antihistamine with anticholinergic effects.
2D Structure
Click here for structure editor
Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 0
Rotatable bonds 4
Topological polar surface area 12.47
Molecular weight 281.18
XLogP 3.7
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
Canonical SMILES CN1CCC(CC1)OC(c1ccccc1)c1ccccc1
Isomeric SMILES CN1CCC(CC1)OC(c1ccccc1)c1ccccc1
InChI InChI=1S/C19H23NO/c1-20-14-12-18(13-15-20)21-19(16-8-4-2-5-9-16)17-10-6-3-7-11-17/h2-11,18-19H,12-15H2,1H3
InChI Key OWQUZNMMYNAXSL-UHFFFAOYSA-N
Immunopharmacology Comments
Diphenylpyraline is an anti-histamine drug.
Immunopharmacology Disease
Disease X-Refs Comment References
Dermatitis Disease Ontology: DOID:2723
Antihistamine approved for dermatitis.
Allergic rhinitis Disease Ontology: DOID:4481
Approved antihistamine for allergic rhinitis, hay fever, and allergic skin disorders.
Allergic urticaria Disease Ontology: DOID:10612
Antihistamine approved for allergic urticaria.
Allergic conjunctivitis Disease Ontology: DOID:11204
Antihistamine approved for allergic conjunctivitis