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Synonyms: ACC-9653-010 | Cerebyx® | CI-982 | Sesquient®
fosphenytoin is an approved drug (FDA (1996))
Compound class: Synthetic organic
Comment: Fosphenytoin is a prodrug of phenytoin. This drug is an anticonvulsant.
Marketed formulations may contain fosphenytoin sodium (PubChem CID 56338).
View more information in the IUPHAR Pharmacology Education Project: fosphenytoin
|No information available.|
|Summary of Clinical Use|
|Fosphenytoin is used to treat grand mal seizures and seizures associated with brain trauma (surgical or accidental). The FDA approved use of Sesquient® as a treatment for status epilepticus in adults and children in November 2020.|
|Mechanism Of Action and Pharmacodynamic Effects|
|This drug blocks sodium channel α subunits (genes SNC1A-SNC11A are listed in this database in the Voltage-gated sodium channels section). This appears to reduce seizure propagation and limit the spread of seizure activity in the brain. See the DrugBank link for further details.|
For extended ADME data see the following:
Electronic Medicines Compendium (eMC)