meclofenamic acid   Click here for help

GtoPdb Ligand ID: 7219

Synonyms: CL-583 | INF-4668 | Meclomen®
Approved drug PDB Ligand Immunopharmacology Ligand
meclofenamic acid is an approved drug
Compound class: Synthetic organic
Comment: Meclofenamic acid is a non-steroidal anti-inflammatory drug (NSAID).
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 3
Hydrogen bond donors 2
Rotatable bonds 3
Topological polar surface area 49.33
Molecular weight 295.02
XLogP 4.75
No. Lipinski's rules broken 0
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Canonical SMILES OC(=O)c1ccccc1Nc1c(Cl)ccc(c1Cl)C
Isomeric SMILES OC(=O)c1ccccc1Nc1c(Cl)ccc(c1Cl)C
InChI InChI=1S/C14H11Cl2NO2/c1-8-6-7-10(15)13(12(8)16)17-11-5-3-2-4-9(11)14(18)19/h2-7,17H,1H3,(H,18,19)
No information available.
Summary of Clinical Use Click here for help
Used to treat muscular pain, arthritis and dysmenorrhea. There is no information regarding approval for clinical use of this drug on the US FDA website. Other national approval agencies may have granted marketing authorisation.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
As with other NSAIDs, this drug reduces prostaglandin synthesis by reducing cyclooxegenase (COX) activity. It also has antipyretic action and stabilises mast cells and reduces their degranulation.