meclofenamic acid   

GtoPdb Ligand ID: 7219

Synonyms: CL-583 | INF-4668 | Meclomen®
meclofenamic acid is an approved drug
Compound class: Synthetic organic
Comment: Meclofenamic acid is a non-steroidal anti-inflammatory drug (NSAID).
2D Structure
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Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 2
Rotatable bonds 3
Topological polar surface area 49.33
Molecular weight 295.02
XLogP 4.75
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
Canonical SMILES OC(=O)c1ccccc1Nc1c(Cl)ccc(c1Cl)C
Isomeric SMILES OC(=O)c1ccccc1Nc1c(Cl)ccc(c1Cl)C
InChI InChI=1S/C14H11Cl2NO2/c1-8-6-7-10(15)13(12(8)16)17-11-5-3-2-4-9(11)14(18)19/h2-7,17H,1H3,(H,18,19)
InChI Key SBDNJUWAMKYJOX-UHFFFAOYSA-N
No information available.
Summary of Clinical Use
Used to treat muscular pain, arthritis and dysmenorrhea. There is no information regarding approval for clinical use of this drug on the US FDA website. Other national approval agencies may have granted marketing authorisation.
Mechanism Of Action and Pharmacodynamic Effects
As with other NSAIDs, this drug reduces prostaglandin synthesis by reducing cyclooxegenase (COX) activity. It also has antipyretic action and stabilises mast cells and reduces their degranulation.