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Synonyms: CL-583 | INF-4668 | Meclomen®
meclofenamic acid is an approved drug
Compound class: Synthetic organic
Comment: Meclofenamic acid is a non-steroidal anti-inflammatory drug (NSAID).
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
1. Kalgutkar AS, Rowlinson SW, Crews BC, Marnett LJ. (2002)
Amide derivatives of meclofenamic acid as selective cyclooxygenase-2 inhibitors.
Bioorg Med Chem Lett, 12 (4): 521-4. [PMID:11844663]
2. Vandewiele F, Pironet A, Jacobs G, Kecskés M, Wegener J, Kerselaers S, Hendrikx L, Verelst J, Philippaert K, Oosterlinck W et al.. (2022)
TRPM4 inhibition by meclofenamate suppresses Ca2+-dependent triggered arrhythmias.
Eur Heart J, 43 (40): 4195-4207. [PMID:35822895]