mirtazapine   Click here for help

GtoPdb Ligand ID: 7241

Synonyms: ORG-3770 | Remeron®
Approved drug
mirtazapine is an approved drug (FDA (1996))
Compound class: Synthetic organic
Comment: Mirtazapine is a tetracyclic antidepressant with complex polypharmacology involving certain adrenergic and serotonin receptors [1]. It also has strong antihistamine effects.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 3
Hydrogen bond donors 0
Rotatable bonds 0
Topological polar surface area 19.37
Molecular weight 265.16
XLogP 3.02
No. Lipinski's rules broken 0
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Canonical SMILES CN1CCN2C(C1)c1ccccc1Cc1c2nccc1
Isomeric SMILES CN1CCN2C(C1)c1ccccc1Cc1c2nccc1
InChI InChI=1S/C17H19N3/c1-19-9-10-20-16(12-19)15-7-3-2-5-13(15)11-14-6-4-8-18-17(14)20/h2-8,16H,9-12H2,1H3
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Summary of Clinical Use Click here for help
Mirtazapine is used to treat major depressive disorder. There is some clinical support for improved clinical effectiveness, in therapies combining dissimilar antidepressants for the treatment of severe depression [5]. For example, combining mirtazapine with a selective serotonin reuptake inhibitor (SSRI) or serotonin norepinephrine reuptake inhibitor (SNRI). Evidence for and against this type of combination therapy is reviewed by Thase (2013) [7].
Mechanism Of Action and Pharmacodynamic Effects Click here for help
Mirtazapine is a centrally acting α2-adrenoceptor antagonist which increases norepinephrine and serotonin release. The increased levels of these neurotransmitters contributes to the drug's anxiolytic effect.
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