Synonyms: ORG-3770 | Remeron®
mirtazapine is an approved drug (FDA (1996))
Compound class:
Synthetic organic
Comment: Mirtazapine is a tetracyclic antidepressant with complex polypharmacology involving certain adrenergic and serotonin receptors [1]. It also has strong antihistamine effects.
![]() Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖![]() View more information in the IUPHAR Pharmacology Education Project: mirtazapine |
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References |
1. Anttila SA, Leinonen EV. (2001)
A review of the pharmacological and clinical profile of mirtazapine. CNS Drug Rev, 7 (3): 249-64. [PMID:11607047] |
2. Fernández J, Alonso JM, Andrés JI, Cid JM, Díaz A, Iturrino L, Gil P, Megens A, Sipido VK, Trabanco AA. (2005)
Discovery of new tetracyclic tetrahydrofuran derivatives as potential broad-spectrum psychotropic agents. J Med Chem, 48 (6): 1709-12. [PMID:15771415] |
3. Kennis LE, Bischoff FP, Mertens CJ, Love CJ, Van den Keybus FA, Pieters S, Braeken M, Megens AA, Leysen JE. (2000)
New 2-substituted 1,2,3,4-tetrahydrobenzofuro[3,2-c]pyridine having highly active and potent central alpha 2-antagonistic activity as potential antidepressants. Bioorg Med Chem Lett, 10 (1): 71-4. [PMID:10636247] |
4. Langham JJ, Cleves AE, Spitzer R, Kirshner D, Jain AN. (2009)
Physical binding pocket induction for affinity prediction. J Med Chem, 52 (19): 6107-25. [PMID:19754201] |
5. Preston TC, Shelton RC. (2013)
Treatment resistant depression: strategies for primary care. Curr Psychiatry Rep, 15 (7): 370. [PMID:23712721] |
6. Proudman RGW, Akinaga J, Baker JG. (2022)
The affinity and selectivity of α-adrenoceptor antagonists, antidepressants and antipsychotics for the human α2A, α2B, and α2C-adrenoceptors and comparison with human α1 and β-adrenoceptors. Pharmacol Res Perspect, 10 (2): e00936. [PMID:35224877] |
7. Thase ME. (2013)
Antidepressant combinations: cutting edge psychopharmacology or passing fad?. Curr Psychiatry Rep, 15 (10): 403. [PMID:24052267] |