phentermine   Click here for help

GtoPdb Ligand ID: 7269

Synonyms: Adipex-P® | Ionamin® | phentermine hydrochloride
Approved drug
phentermine is an approved drug (FDA (1959))
Compound class: Synthetic organic
Comment: Phentermine is a stimulant similar to amphetamines.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 1
Hydrogen bond donors 1
Rotatable bonds 2
Topological polar surface area 26.02
Molecular weight 149.12
XLogP 2.18
No. Lipinski's rules broken 0
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Canonical SMILES CC(Cc1ccccc1)(N)C
Isomeric SMILES CC(Cc1ccccc1)(N)C
InChI InChI=1S/C10H15N/c1-10(2,11)8-9-6-4-3-5-7-9/h3-7H,8,11H2,1-2H3
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Summary of Clinical Use Click here for help
Used as an appetite suppressant to aid weight loss in programmes which include diet and exercise. This drug is not approved for use in the EU.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
The main action of this drug is to inhibit noepinephrine reuptake by the transporter SLC6A2. The resulting increase in free noepinephrine appears to suppress appetite and hunger signals. The drug may have other mechanistic actions. See the DrugBank link for further details.
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