prilocaine   Click here for help

GtoPdb Ligand ID: 7276

Synonyms: ASTRA 1512 | L-67 | Prilotekal®
Approved drug
prilocaine is an approved drug (FDA (1965))
Compound class: Synthetic organic
Comment: Prilocaine is often an active ingredient in fixed-mixture medications along with lidocaine.
Marketed formulations may contain prilocaine hydrochloride (PubChem CID 92163).
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 3
Hydrogen bond donors 2
Rotatable bonds 5
Topological polar surface area 44.62
Molecular weight 220.16
XLogP 2.4
No. Lipinski's rules broken 0
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Canonical SMILES CCCNC(C(=Nc1ccccc1C)O)C
Isomeric SMILES CCCNC(C(=Nc1ccccc1C)O)C
InChI InChI=1S/C13H20N2O/c1-4-9-14-11(3)13(16)15-12-8-6-5-7-10(12)2/h5-8,11,14H,4,9H2,1-3H3,(H,15,16)
No information available.
Summary of Clinical Use Click here for help
Prilocaine is a local anesthetic used commonly in dental practice, administered parenterally by injection to induce nerve block. This drug may also be used to induce spinal anaesthesia for short term surgical procedures.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
Prilocaine blocks sodium channels located on neuronal membranes and thereby inhibits action potential and nerve signal propagation. The genes and proteins SNC1A-SNC11A are listed in this database in the voltage-gated sodium channels section.
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