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Synonyms: ASTRA 1512 | L-67 | Prilotekal®
prilocaine is an approved drug (FDA (1965))
Compound class: Synthetic organic
Comment: Prilocaine is often an active ingredient in fixed-mixture medications along with lidocaine.
Marketed formulations may contain prilocaine hydrochloride (PubChem CID 92163).
View more information in the IUPHAR Pharmacology Education Project: prilocaine
|No information available.|
|Summary of Clinical Use|
|Prilocaine is a local anesthetic used commonly in dental practice, administered parenterally by injection to induce nerve block. This drug may also be used to induce spinal anaesthesia for short term surgical procedures.|
|Mechanism Of Action and Pharmacodynamic Effects|
|Prilocaine blocks sodium channels located on neuronal membranes and thereby inhibits action potential and nerve signal propagation. The genes and proteins SNC1A-SNC11A are listed in this database in the voltage-gated sodium channels section.|
For extended ADME data see the following:
Electronic Medicines Compendium (eMC)