ropinirole   

GtoPdb Ligand ID: 7295

Synonyms: Requip® | SK&F-101468-A | SK&F-101468A
ropinirole is an approved drug (FDA (1997), EMA (2006))
Compound class: Synthetic organic
Comment: Ropinirole is a dopamine agonist. This drug is active at the dopamine-D2 and -D3 receptor subtypes, both centrally and peripherally.
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2D Structure
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Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 7
Topological polar surface area 35.83
Molecular weight 260.19
XLogP 2.56
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
Canonical SMILES CCCN(CCC)CCc1cccc2c1CC(=N2)O
Isomeric SMILES CCCN(CCC)CCc1cccc2c1CC(=N2)O
InChI InChI=1S/C16H24N2O/c1-3-9-18(10-4-2)11-8-13-6-5-7-15-14(13)12-16(19)17-15/h5-7H,3-4,8-12H2,1-2H3,(H,17,19)
InChI Key UHSKFQJFRQCDBE-UHFFFAOYSA-N
No information available.
Summary of Clinical Use
Used in the treatment of Parkinson's disease and restless legs syndrome (RLS)
Mechanism Of Action and Pharmacodynamic Effects
This drug acts as replacement therapy to normalise the low levels of cerebral dopamine which are associated with Parkinson's disease. The exact mechanism by which the drug improves the symptoms of its indicated conditions is not fully understood. See the DrugBank link for further details.
External links