aclidinium   Click here for help

GtoPdb Ligand ID: 7449

Synonyms: LAS W-330 | LAS-34273 | Tudorza Pressair®
Approved drug
aclidinium is an approved drug (FDA and EMA (2012))
Compound class: Synthetic organic
Comment: Note that the approved drug is the bromide salt (PubChem CID 11434515).
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 10
Topological polar surface area 112.24
Molecular weight 484.16
XLogP 3.18
No. Lipinski's rules broken 0
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Canonical SMILES O=C(C(c1cccs1)(c1cccs1)O)OC1C[N+]2(CCCOc3ccccc3)CCC1CC2
Isomeric SMILES O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2
InChI InChI=1S/C26H30NO4S2/c28-25(26(29,23-9-4-17-32-23)24-10-5-18-33-24)31-22-19-27(14-11-20(22)12-15-27)13-6-16-30-21-7-2-1-3-8-21/h1-5,7-10,17-18,20,22,29H,6,11-16,19H2/q+1/t20?,22-,27?/m0/s1
No information available.
Summary of Clinical Use Click here for help
Approved to treat and prevent bronchospasm in adults with chronic bronchitis, emphysema, or other forms of chronic obstructive pulmonary disease (COPD) [1]. This drug can be used as long-term maintainence therapy and requires use only once daily. In November 2014, the EU EMA granted marketing authorisation of the fixed-dose combination medication Duaklir Genuair TM (aclidinium bromide/formoterol fumarate) as a maintenance bronchodilator for patients with chronic obstructive pulmonary disease (COPD).
Mechanism Of Action and Pharmacodynamic Effects Click here for help
Aclidinium bromide is a long-acting, anticholinergic/antimuscarinic bronchodilator [2]. The drug competitively and reversibly inhibits the action of acetylcholine at type 3 muscarinic (M3) receptors in bronchial smooth muscle. This causes a reduction in smooth muscle contraction, ie the bronchodilatory effect that eases breathing.
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