fesoterodine   Click here for help

GtoPdb Ligand ID: 7473

Synonyms: SPM-8272 | SPM-907 | Toviaz®
Approved drug
fesoterodine is an approved drug (EMA (2007), FDA (2008))
Compound class: Synthetic organic
Comment: The marketed formulation contains the fumarate compound (PubChem CID 9849808). Fesoterodine is an antimuscarinic prodrug, with the active metabolite being 5-hydroxymethyl tolterodine (5-HMT, PubChem CID 9819382).
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 11
Topological polar surface area 49.77
Molecular weight 411.28
XLogP 5.07
No. Lipinski's rules broken 2
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Canonical SMILES OCc1ccc(c(c1)C(c1ccccc1)CCN(C(C)C)C(C)C)OC(=O)C(C)C
Isomeric SMILES OCc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)OC(=O)C(C)C
InChI InChI=1S/C26H37NO3/c1-18(2)26(29)30-25-13-12-21(17-28)16-24(25)23(22-10-8-7-9-11-22)14-15-27(19(3)4)20(5)6/h7-13,16,18-20,23,28H,14-15,17H2,1-6H3/t23-/m1/s1
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Summary of Clinical Use Click here for help
Approved to treat the symptoms (increased urinary frequency and/or urgency and/or urgency incontinence) that occur in patients with overactive bladder syndrome.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
Fesoterodine is an antagonist of muscarinic acetylcholine receptors M2 and M3. Antimuscarinic drugs are the main treatment option for overactive bladder syndrome [1]. Drug action relaxes the smooth muscle of the bladder wall, increasing volume and decreasing urgency.
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