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Synonyms: GS-9350
cobicistat is an approved drug (FDA (2012), EMA (2013))
Compound class:
Synthetic organic
Comment: This compound is approved as a component of the so-called 'Quad pill' (Stribild®), an anti-HIV therapy which contains cobicistat, elvitegravir, emtricitabine, and tenofovir.
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No information available. |
Summary of Clinical Use ![]() |
Used as a pharmacokinetic booster, to enhance systemic exposure to anti-HIV drugs. |
Mechanism Of Action and Pharmacodynamic Effects ![]() |
Cobicistat inhibits metabolic liver enzymes, in particular the cytochrome P450 3A subtype, CYP3A4 [3]. The CYP3A enzymes are known to breakdown and inactivate antiviral drugs such as elvitegravir (an HIV integrase inhibitor), although cobicistat has no intrinsic antiviral activity [2]. Additionally, cobicistat appears to inhibit intestinal transport proteins, thus increasing absorption of other anti-HIV drugs such as atazanavir, darunavir and tenofovir alafenamide fumarate [1]. |