amfenac   Click here for help

GtoPdb Ligand ID: 7565

Synonyms: AHR-5850D | Fenazox® (Japan)
Approved drug
amfenac is an approved drug
Compound class: Synthetic organic
Comment: Amfenac is the active metabolite of nepafenac. It is a potent non-steroidal antiinflammatory drug (NSAID) [2].
Marketed formulations may contain amfenac sodium (PubChem CID 23665728).
2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 4
Hydrogen bond donors 2
Rotatable bonds 4
Topological polar surface area 80.39
Molecular weight 255.09
XLogP 2.62
No. Lipinski's rules broken 0
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Canonical SMILES OC(=O)Cc1cccc(c1N)C(=O)c1ccccc1
Isomeric SMILES OC(=O)Cc1cccc(c1N)C(=O)c1ccccc1
InChI InChI=1S/C15H13NO3/c16-14-11(9-13(17)18)7-4-8-12(14)15(19)10-5-2-1-3-6-10/h1-8H,9,16H2,(H,17,18)
No information available.
Summary of Clinical Use Click here for help
Appears to be licensed only in Japan. As with its prodrug, nepafenac, amfenac may be used to treat the pain and inflammation caused by cataract surgery [1].
Mechanism Of Action and Pharmacodynamic Effects Click here for help
As with other NSAIDs, this drug reduces prostaglandin synthesis by reducing cyclooxegenase (COX) activity.