amfenac   Click here for help

GtoPdb Ligand ID: 7565

Synonyms: AHR-5850D | Fenazox® (Japan)
Approved drug
amfenac is an approved drug
Compound class: Synthetic organic
Comment: Amfenac is the active metabolite of nepafenac. It is a potent non-steroidal antiinflammatory drug (NSAID) [2].
Marketed formulations may contain amfenac sodium (PubChem CID 23665728).
2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 4
Hydrogen bond donors 2
Rotatable bonds 4
Topological polar surface area 80.39
Molecular weight 255.09
XLogP 2.62
No. Lipinski's rules broken 0
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Canonical SMILES OC(=O)Cc1cccc(c1N)C(=O)c1ccccc1
Isomeric SMILES OC(=O)Cc1cccc(c1N)C(=O)c1ccccc1
InChI InChI=1S/C15H13NO3/c16-14-11(9-13(17)18)7-4-8-12(14)15(19)10-5-2-1-3-6-10/h1-8H,9,16H2,(H,17,18)
1. Jones BM, Neville MW. (2013)
Nepafenac: an ophthalmic nonsteroidal antiinflammatory drug for pain after cataract surgery.
Ann Pharmacother, 47 (6): 892-6. [PMID:23715071]
2. Welstead Jr WJ, Moran HW, Stauffer HF, Turnbull LB, Sancilio LF. (1979)
Antiinflammatory agents. 1. Synthesis and antiinflammatory activity of 2-amino-3-benzoylphenylacetic acid.
J Med Chem, 22 (9): 1074-9. [PMID:490552]