peginterferon beta-1a   Click here for help

GtoPdb Ligand ID: 7637

Synonyms: interferon beta 1-alpha | PEG-INF-β-1a | Plegridy®
Approved drug Immunopharmacology Ligand
peginterferon beta-1a is an approved drug (EMA and FDA (2014))
Comment: This drug is a PEGylated version of recombinant human interferon beta-1a [1].
No information available.
Summary of Clinical Use Click here for help
Approved for the treatment of relapsing-remitting multiple sclerosis. See Calabresi et al (2014) [2] for the reults of the Phase 3 ADVANCE clinical trial. (NCT00906399).
Mechanism Of Action and Pharmacodynamic Effects Click here for help
Interferon-beta-1a reduces the auto-immune attack on the protective sheath around the nerves which causes MS flare-ups, and thus reduces relapses. PEGylation of the cytokine increases the circulating half-life of the cytokine and thereby extends the administration interval to bi-weekly.