AZD6703   Click here for help

GtoPdb Ligand ID: 7687

Synonyms: AZ 12012199 | AZ-12012199 | AZ12012199 | AZD 6703 | AZD-6703
PDB Ligand Immunopharmacology Ligand
Compound class: Synthetic organic
Comment: AZD6703 is a potent, selective and reversible orally bioavailable inhibitor of p38 mitogen-activated protein kinase 14 (MAPK14).
This compound was in the AstraZeneca/MRC repurposing list from 2011.
Click here for help
2D Structure
Click here for help
Click here for structure editor
Physico-chemical Properties
Click here for help
Hydrogen bond acceptors 6
Hydrogen bond donors 1
Rotatable bonds 5
Topological polar surface area 69.95
Molecular weight 417.22
XLogP 3.31
No. Lipinski's rules broken 0
Click here for help
Canonical SMILES CN1CCN(CC1)c1ccc2c(c1)c(=O)n(cn2)c1cc(ccc1C)C(=O)NC1CC1
Isomeric SMILES CN1CCN(CC1)c1ccc2c(c1)c(=O)n(cn2)c1cc(ccc1C)C(=O)NC1CC1
InChI InChI=1S/C24H27N5O2/c1-16-3-4-17(23(30)26-18-5-6-18)13-22(16)29-15-25-21-8-7-19(14-20(21)24(29)31)28-11-9-27(2)10-12-28/h3-4,7-8,13-15,18H,5-6,9-12H2,1-2H3,(H,26,30)
No information available.
Summary of Clinical Use Click here for help
AZD6703 was investigated as a potential treatment for inflammatory diseases such as osteoarthritis.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
AZD6703 is an inhibitor of p38a MAP kinase (MAPK14). p38α mitogen-activated protein kinase (MAPK) is critical for the regulation of pro-inflammatory cytokines such as tumour necrosis factor alpha (TNF-α) and interleukin-1β (IL-1β). Over production of these cytokines is linked to the inflammatory processes driving a broad range of diseases including rheumatoid arthritis, psoriasis, inflammatory bowel disease, multiple sclerosis, ischaemia [2], Alzheimer's disease, and neuropathic pain [3-4].