Ligand id: 7946

Name: sotrastaurin

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 2
Rotatable bonds 3
Topological polar surface area 94.22
Molecular weight 438.18
XLogP 2.96
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Sotrastaurin (AEB071) has been assessed in a number of clinical trials, for a wide variety of oncology indications, in autoimmune conditions such as plaque psoriasis, and also as an anti-rejection therapy following kidney/liver transplantation. Link here to's listing of currently registered sotrastaurin trials. The only open trial (May 2017) is Phase 1 NCT02273219 in uveal melanoma.