Ligand id: 8000

Name: tabalumab

No information available.
Summary of Clinical Use
Tabalumab progressed to Phase 3 clinical evaluation in patients with SLE [5] and rheumatoid arthritis, but trials in these conditions were terminated due to an observed lack of efficacy. Click here to link to complete list of tabalumab studies.
Mechanism Of Action and Pharmacodynamic Effects
BAFF acts as an immunostimulant, and is required for the formation, maintenance and survival of B cells [4], and it is thus important for maintaining normal immunity. Over-production of BAFF is implicated in the aberrant production of antibodies associated with autoimmune conditions such as rheumatoid arthritis and systemic lupus erythmatosis. Tabalumab was predicted to limit the effect of abnormal BAFF secretion, reduce reactive antibody production and thereby improve disease symptoms.