Ligand id: 8000

Name: tabalumab

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Bioactivity Comments
In patent US7317089 a KD for the interaction between antibody 4A5-3.1.1-B4 and human TNFSF13B is reported as 38µM [3]. However, this appears to be a very low affinity, considering the patent abstract suggests a requirement for the KD to be <10nM. We have therefore entered the 10nM figure in the interaction table below.
Selectivity at ligand targets
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
BAFF Hs Antibody Binding 8.0 pKd - 3
pKd 8.0 (Kd 1x10-8 M) [3]