tabalumab   

GtoPdb Ligand ID: 8000

Synonyms: LY 2127399 | LY2127399
Compound class: Antibody
Comment: Tabalumab is a monoclonal antibody directed against B-cell activating factor (BAFF, TNFSF13B). It was being developed as a treatment for autoimmune diseases [1] and B cell malignancies [2].
Peptide sequence and structural information for this antibody are available from its IMGT/mAb-db record. Peptide sequence BLAST search using the heavy chain variable region of tabalumab provides 100% match to a sequence claimed in patent US7317089 [3], and to the antibody with designation 4A5-3.1.1-B4.
Bioactivity Comments
In patent US7317089 a KD for the interaction between antibody 4A5-3.1.1-B4 and human TNFSF13B is reported as 38µM [3]. However, this appears to be a very low affinity, considering the patent abstract suggests a requirement for the KD to be <10nM. We have therefore entered the 10nM figure in the interaction table below.
Selectivity at ligand targets
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
BAFF Hs Antibody Binding 8.0 pKd - 3
pKd 8.0 (Kd 1x10-8 M) [3]