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Synonyms: LY 2127399 | LY2127399
Compound class:
Antibody
Comment: Tabalumab is a monoclonal antibody directed against B-cell activating factor (BAFF, TNFSF13B). It was being developed as a treatment for autoimmune diseases [1] and B cell malignancies [2].
Peptide sequence and structural information for this antibody are available from its IMGT/mAb-db record. Peptide sequence BLAST search using the heavy chain variable region of tabalumab provides 100% match to a sequence claimed in patent US7317089 [3], and to the antibody with designation 4A5-3.1.1-B4. |
| Bioactivity Comments |
| In patent US7317089 a KD for the interaction between antibody 4A5-3.1.1-B4 and human TNFSF13B is reported as 38µM [3]. However, this appears to be a very low affinity, considering the patent abstract suggests a requirement for the KD to be <10nM. We have therefore entered the 10nM figure in the interaction table below. |
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