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Synonyms: LY 2127399 | LY2127399
Compound class: Antibody
Comment: Tabalumab is a monoclonal antibody directed against B-cell activating factor (BAFF, TNFSF13B). It was being developed as a treatment for autoimmune diseases  and B cell malignancies .
Peptide sequence and structural information for this antibody are available from its IMGT/mAb-db record. Peptide sequence BLAST search using the heavy chain variable region of tabalumab provides 100% match to a sequence claimed in patent US7317089 , and to the antibody with designation 4A5-3.1.1-B4.
|Tabalumab is a failed Phase 3 anti-BAFF monoclonal antibody. It provided no clinical efficacy in patients with rheumatoid arthritis or SLE.|
|Tabalumab was a clinical candidate therapeutic for RA.|
|Systemic lupus erythematosus||
|Tabalumab was a clinical candidate therapeutic for SLE.|