tabalumab   Click here for help

GtoPdb Ligand ID: 8000

Synonyms: LY 2127399 | LY2127399
Immunopharmacology Ligand
Compound class: Antibody
Comment: Tabalumab is a monoclonal antibody directed against B-cell activating factor (BAFF, TNFSF13B). It was being developed as a treatment for autoimmune diseases [1] and B cell malignancies [2].
Peptide sequence and structural information for this antibody are available from its IMGT/mAb-db record. Peptide sequence BLAST search using the heavy chain variable region of tabalumab provides 100% match to a sequence claimed in patent US7317089 [3], and to the antibody with designation 4A5-3.1.1-B4.
Immunopharmacology Comments
Tabalumab is a failed Phase 3 anti-BAFF monoclonal antibody. It provided no clinical efficacy in patients with rheumatoid arthritis or SLE.
Immunopharmacology Disease
Disease X-Refs Comment References
Rheumatoid arthritis Disease Ontology: DOID:7148
OMIM: 180300
Tabalumab was a clinical candidate therapeutic for RA.
Systemic lupus erythematosus Disease Ontology: DOID:9074
OMIM: 152700
Orphanet: ORPHA536
Tabalumab was a clinical candidate therapeutic for SLE.