Synonyms: (1RS,2RS)-2-[(dimethylamino)methyl]-1-(3-methoxyphenyl)-cyclo-hexanol | Maxitram® | Tilodol® | Tramacet®
tramadol is an approved drug (FDA (1995), UK (2003))
Compound class:
Synthetic organic
Comment: Tramadol is a narcotic-like analgesic.
The marketed formulation of tramadol is a racemic mixture of enantiomers, including PubChem CIDs 33741 and 667511 (and others). We represent the non-isomeric molecule to represent the mixture. The clinically administered form is tramadol hydrochloride. ![]() Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖![]() View more information in the IUPHAR Pharmacology Education Project: tramadol |
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No information available. |
Summary of Clinical Use ![]() |
Tramadol is indicated for the symptomatic treatment of moderate to severe pain. |
Mechanism Of Action and Pharmacodynamic Effects ![]() |
Tramadol acts via non-selective agonism of opioid receptors [1] to activate the spinal pain inhibitory system, with additional effects on the neurotransmission of noradrenalin and serotonin (descending inhibitory system, non-opioid effect) [2-3]. |
External links ![]() |
For extended ADME data see the following: Electronic Medicines Compendium (eMC) |