- Advanced search
- Immuno Portal
- Malaria Portal
Synonyms: (1RS,2RS)-2-[(dimethylamino)methyl]-1-(3-methoxyphenyl)-cyclo-hexanol | Maxitram® | Tilodol® | Tramacet®
tramadol is an approved drug (FDA (1995), UK (2003))
Compound class: Synthetic organic
Comment: Tramadol is a narcotic-like analgesic.
The marketed formulation of tramadol is a racemic mixture of enantiomers, including PubChem CIDs 33741 and 667511 (and others). We represent the non-isomeric molecule to represent the mixture. The clinically administered form is tramadol hydrochloride.
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
View more information in the IUPHAR Pharmacology Education Project: tramadol
1. Hennies HH, Friderichs E, Schneider J. (1988)
Receptor binding, analgesic and antitussive potency of tramadol and other selected opioids.
Arzneimittelforschung, 38 (7): 877-80. [PMID:2849950]
2. Leppert W. (2009)
Tramadol as an analgesic for mild to moderate cancer pain.
Pharmacol Rep, 61 (6): 978-92. [PMID:20081232]
3. Raffa RB, Friderichs E, Reimann W, Shank RP, Codd EE, Vaught JL. (1992)
Opioid and nonopioid components independently contribute to the mechanism of action of tramadol, an 'atypical' opioid analgesic.
J Pharmacol Exp Ther, 260 (1): 275-85. [PMID:1309873]
4. Wentland MP, Lou R, Lu Q, Bu Y, Denhardt C, Jin J, Ganorkar R, VanAlstine MA, Guo C, Cohen DJ et al.. (2009)
Syntheses of novel high affinity ligands for opioid receptors.
Bioorg Med Chem Lett, 19 (8): 2289-94. [PMID:19282177]
5. Wentland MP, Lou R, Lu Q, Bu Y, VanAlstine MA, Cohen DJ, Bidlack JM. (2009)
Syntheses and opioid receptor binding properties of carboxamido-substituted opioids.
Bioorg Med Chem Lett, 19 (1): 203-8. [PMID:19027293]