IFN-β1b (recombinant human)   Click here for help

GtoPdb Ligand ID: 8340

Synonyms: Betaferon® | Betaseron® | Extavia® | IFNb1b
Approved drug Immunopharmacology Ligand
IFN-β1b (recombinant human) is an approved drug (FDA (1993), EMA (1995))
Comment: Compared to the sequence of endogenous IFN-β, IFN-β1b has a Ser to Cys substitution at position 17, but does not retain the glycosylation site at Asn80. It also lacks the initiating Met. This recombinant peptide is produced in E.coli.
No information available.
Summary of Clinical Use Click here for help
Like IFN-β1a (recombinant human), IFN-β1b is used to treat relapsing forms of multiple sclerosis [1-2].
Mechanism Of Action and Pharmacodynamic Effects Click here for help
IFN-β1b activates Type I interferon receptors and induces expression of genes involved in antiviral, immunomodulatory and antiproliferative effects. The mechanism of action underlying the therapeutic benefit of IFN-β1b therapy remains unclear.