Ligand id: 8427

Name: relenopride

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 3
Rotatable bonds 11
Topological polar surface area 119.91
Molecular weight 492.19
XLogP 3.22
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
YKP10811 has reached Phase II clinical trial as a potential treatment for chronic constipation, either idiopathic or as a result of irritable bowel syndrome.
Mechanism Of Action and Pharmacodynamic Effects
The 5-HT4 receptor subtype is physiologically and pathophysiologically important for the regulation of intestinal peristalsis and gut motility [1,5-6]. Activation of these receptors in the gut wall enhances the peristaltic reflex [2], relaxes the smooth muscle and increases fluid secretion in the gastrointestinal (GI) tract [4]. All of these actions improve transit in GI functional disorders.