aTyr 1940   Click here for help

GtoPdb Ligand ID: 8738

Synonyms: ATYR1940 | HRS(1-506) | Resolaris
Comment: aTyr 1940 is a recombinant 506 amino acid version of human histidyl-tRNA synthetase (cytoplasmic isoform 1) (HARS; P12081) [1]. HARS belongs to a novel group of naturally occurring proteins termed 'physiocrines' which are extracellular signaling regions of tRNA synthetases reported to modulate immune system pathways. Physiocrines are of interest to the pharmaceutical industry as molecular targets for immunomodulatory therapies (see patents WO2013123432 A2 and US20150093799 A1 for further details [1-2]). See also resokine, a shorter variant of aTyr 1940.
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Summary of Clinical Use Click here for help
ATYR1940 is being evaluated in Phase 1/II clinical trial as a potential therapy for facioscapulohumeral muscular dystrophy (NCT02239224).
Clinical Trials
Clinical Trial ID Title Type Source Comment References
NCT02239224 Safety, Tolerability, Pharmacokinetics, and Biological Activity of ATYR1940 in Adult Patients With Muscular Dystrophy Phase 1/Phase 2 Interventional aTyr Pharma, Inc.