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Synonyms: ATYR1940 | HRS(1-506) | Resolaris
Compound class:
Peptide or derivative
Comment: aTyr 1940 is a recombinant 506 amino acid version of human histidyl-tRNA synthetase (cytoplasmic isoform 1) (HARS; P12081) [1]. HARS belongs to a novel group of naturally occurring proteins termed 'physiocrines' which are extracellular signaling regions of tRNA synthetases reported to modulate immune system pathways. Physiocrines are of interest to the pharmaceutical industry as molecular targets for immunomodulatory therapies (see patents WO2013123432 A2 and US20150093799 A1 for further details [1-2]). See also resokine, a shorter variant of aTyr 1940.
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| References |
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1. Chiang KP, Gardiner E, Lau C-F, Lo W-S, Greve J, Ashlock M, Mendlein JD. (2015)
Histidyl-trna synthetases for treating autoimmune and inflammatory diseases. Patent number: US20150093799 A1. Assignee: Atyr Pharma, Inc.. Priority date: 16/02/2012. Publication date: 02/04/2015. |
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2. Chiang KP, Gardiner E, Lau CF, Lo W-S, Greve J, Ashlock M, Mendlein JD. (2013)
Histidyl-trna synthetases for treating autoimmune and inflammatory diseases. Patent number: WO2013123432 A2. Assignee: Atyr Pharma, Inc., Pangu Biopharma Limited. Priority date: 16/02/2012. Publication date: 22/08/2013. |
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3. Hochberg MC, Feldman D, Stevens MB, Arnett FC, Reichlin M. (1984)
Antibody to Jo-1 in polymyositis/dermatomyositis: association with interstitial pulmonary disease. J Rheumatol, 11 (5): 663-5. [PMID:6334746] |
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4. Zampieri S, Ghirardello A, Iaccarino L, Tarricone E, Gambari PF, Doria A. (2005)
Anti-Jo-1 antibodies. Autoimmunity, 38 (1): 73-8. [PMID:15804708] |
