compound 13b [PMID: 19101153]   

GtoPdb Ligand ID: 8808

Compound class: Synthetic organic
Comment: Compound 13b is one of a series of experimantal compounds tested as KATP channel openers [1], with the aim of discovering leads structures which could be developed in to drugs to treat urge urinary incontinence (overactive bladder). Functional KATP channels in the smooth muscle of the bladder are complexes of the sulfonylurea receptor 2 (SUR2; ABCC9) and the inwardly rectifying potassium channel subunit (Kir6.2; KCNJ11).
2D Structure
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Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 1
Topological polar surface area 88.39
Molecular weight 370.07
XLogP 3.09
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
Canonical SMILES N#Cc1ccc2c(c1)C(n1oc3c(c1=O)ccc(c3)Cl)C(C(O2)(C)C)O
Isomeric SMILES N#Cc1ccc2c(c1)[C@@H](n1oc3c(c1=O)ccc(c3)Cl)[C@@H](C(O2)(C)C)O
InChI InChI=1S/C19H15ClN2O4/c1-19(2)17(23)16(13-7-10(9-21)3-6-14(13)25-19)22-18(24)12-5-4-11(20)8-15(12)26-22/h3-8,16-17,23H,1-2H3/t16-,17+/m1/s1
InChI Key LSWVRWFSRJQEKB-SJORKVTESA-N
No information available.
Mechanism Of Action and Pharmacodynamic Effects
Compound 13 is hypothesized to suppress involuntary bladder contractions by reducing KATP channel-induced cell hyperpolarization and cellular excitability of smooth muscle cells.