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Synonyms: AR 12286 | AR-12286
Compound class: Synthetic organic
Comment: Verosudil is an investigational Rho kinase inhibitor.
The INN record for verosudil indicates that this is a racemic mixture. We show the chemical structure without stereochemistry to represent the mixture. The (2S)-isomer is represented in PubChem CID 86270580 and the (2R)-isomer is represented in CID 44198631.
|No information available.|
|Summary of Clinical Use|
|Verosudil is being evaluated in Phase II clinical trial for its potential to reduce intraocular pressure in patients diagnosed with ocular hypertension or glaucoma . Click here to link to ClinicalTrials.gov's listing of AR-12286 trials.|
|Mechanism Of Action and Pharmacodynamic Effects|
|Non-human primate studies suggest that AR-12286 lowers intraocular pressure primarily by increasing aqueous humor outflow through the trabecular meshwork, as do other Rho kinase inhibitors such as fasudil and Y27632.|