Ligand id: 8935

Name: lenzilumab

No information available.
Summary of Clinical Use
Lenzilumab has completed Phase II clinical trial for uncontrolled asthma, whereas a Phase II study in patients with inadequately controlled rheumatoid arthritis has been terminated. A Phase I trial in patients with previously treated chronic myelomonocytic leukemia (CMML) is ongoing [3].
Mechanism Of Action and Pharmacodynamic Effects
The antibody functionally neutralizes soluble GM-CSF. The potential clinical utility of anti-GM-CSF therapy is discussed in [2].
In CMML, cancer cells are hypersensitive to GM-CSF, with their cell growth and survival stimulated in the presence of very low levels of this cytokine. Using lenzilumab to neutralise GM-CSF in in vitro experiments kills CMML cells.