lenzilumab   Click here for help

GtoPdb Ligand ID: 8935

Synonyms: KB-003 | KB003
Immunopharmacology Ligand
Compound class: Antibody
Comment: Lenzilumab is a fully human IgG1κ moncolonal antibody targeting granulocyte-macrophage colony-stimulating factor (GM-CSF), being investigated for its immunomodulatory potential.
Peptide sequences for this antibody are available from its IMGT/mAb-DB record.
BLAST peptide searches using the variable regions of the heavy and light chains of the antibody reveal exact matches with sequences submitted with patent US8075885 B2 [1].
Selectivity at ligand targets
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
GM-CSF Primary target of this compound Hs Antibody Binding >10.0 pKd - 1
⤷ pKd >10.0 (Kd <1x10-10 M) [1]