lenzilumab   Click here for help

GtoPdb Ligand ID: 8935

Synonyms: KB-003 | KB003
Immunopharmacology Ligand
Compound class: Antibody
Comment: Lenzilumab is a fully human IgG1κ moncolonal antibody targeting granulocyte-macrophage colony-stimulating factor (GM-CSF), being investigated for its immunomodulatory potential.
Peptide sequences for this antibody are available from its IMGT/mAb-DB record.
BLAST peptide searches using the variable regions of the heavy and light chains of the antibody reveal exact matches with sequences submitted with patent US8075885 B2 [1].
Immunopharmacology Disease
Disease X-Refs Comment References
B-cell chronic lymphocytic leukemia OMIM: 151400
Orphanet: ORPHA67038
Phase 1 clinical candidate for CLL (see NCT02546284).
Rheumatoid arthritis Disease Ontology: DOID:7148
OMIM: 180300
Clinical candidate for RA (maximum Phase 2).
Asthma Disease Ontology: DOID:2841
OMIM: 600807
Clinical candidate for asthma (maximum Phase 2).