|
Synonyms: KB-003 | KB003
Compound class:
Antibody
Comment: Lenzilumab is a fully human IgG1κ moncolonal antibody targeting granulocyte-macrophage colony-stimulating factor (GM-CSF), being investigated for its immunomodulatory potential.
Peptide sequences for this antibody are available from its IMGT/mAb-DB record. BLAST peptide searches using the variable regions of the heavy and light chains of the antibody reveal exact matches with sequences submitted with patent US8075885 B2 [1]. |
| Immunopharmacology Disease | |||
| Disease | X-Refs | Comment | References |
| B-cell chronic lymphocytic leukemia |
OMIM:
151400 Orphanet: ORPHA67038 |
Phase 1 clinical candidate for CLL (see NCT02546284). | |
| Rheumatoid arthritis |
Disease Ontology:
DOID:7148 OMIM: 180300 |
Clinical candidate for RA (maximum Phase 2). | |
| Asthma |
Disease Ontology:
DOID:2841 OMIM: 600807 |
Clinical candidate for asthma (maximum Phase 2). | |
