BIA 10-2474

Ligand id: 9001

Name: BIA 10-2474

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 0
Rotatable bonds 4
Topological polar surface area 65.07
Molecular weight 300.16
XLogP 2.52
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
A first-in-human Phase I clinical trial of BIA 10-2474 (EudraCT No: 2015-001799-24) was terminated when the first healthy volunteers to receive multiple ascending doses of the compound became severely ill, with one fatality. See the Nature News article Researchers question design of fatal French clinical trial for further analysis of this case. It is worth noting that various other FAAH inhibitors have been investigated in clinical trials without experiencing such adverse events (see JNJ-42165279 and PF-04457845 for example, both of which are in Phase II).