ADL5747   Click here for help

GtoPdb Ligand ID: 9003

Synonyms: ADL 5747 | ADL-5747 | compound 36 [PMID: 19694468]
Compound class: Synthetic organic
Comment: ADL5747 is a selective, nonpeptidic δ opioid receptor agonist [1]. Due to its favorable efficacy, safety, and pharmacokinetic profile ADL5747 was progressed as a clinical candidate for the treatment of pain.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 3
Hydrogen bond donors 2
Rotatable bonds 5
Topological polar surface area 61.8
Molecular weight 392.21
XLogP 3.98
No. Lipinski's rules broken 0
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Canonical SMILES CCN(C(=O)c1ccc(c(c1)O)C1=CC2(CCNCC2)Oc2c1cccc2)CC
Isomeric SMILES CCN(C(=O)c1ccc(c(c1)O)C1=CC2(CCNCC2)Oc2c1cccc2)CC
InChI InChI=1S/C24H28N2O3/c1-3-26(4-2)23(28)17-9-10-18(21(27)15-17)20-16-24(11-13-25-14-12-24)29-22-8-6-5-7-19(20)22/h5-10,15-16,25,27H,3-4,11-14H2,1-2H3
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Summary of Clinical Use Click here for help
A Phase 2 clinical trial (NCT01058642) evaluating ADL5747's analgesic effect in patients with postherpetic neuralgia has been terminated.
Clinical Trials
Clinical Trial ID Title Type Source Comment References
NCT01058642 Study to Assess the Efficacy, Safety, and Tolerability of ADL5747 in Participants With Postherpetic Neuralgia Phase 2 Interventional Cubist Pharmaceuticals LLC