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Synonyms: Elocon® (topical) | Nasonex®
mometasone is an approved drug (1987 (FDA))
Compound class: Synthetic organic
Comment: Mometasone is a corticosteroid anti-inflammatory drug.
View more information in the IUPHAR Pharmacology Education Project: mometasone
|No information available.|
|Summary of Clinical Use|
|Mometasone is used intranasally in the management of asthma, allergic rhinitis and nasal polyposis, and topically for allergic skin disorders. Prescribed formulations contain mometasone furoate (PubChem CID 441336).
A fixed-dose combination of indacaterol/glycopyrrolate/mometasone furoate (QVM149, Enerzair® Breezhaler®) has completed Phase 3 evaluation as a once-daily therapy for uncontrolled asthma . Results confirmed non-inferiority to twice-daily salmeterol/fluticasone high-dose + tiotropium, and using a medium-dose had comparable efficacy but at a corresponding lower steroid dose.
|Mechanism Of Action and Pharmacodynamic Effects|
|The antiinflammatory actions of corticosteroids are thought to involve inhibition of several pathways involved in resolution of inflammation, including inhibition of cytosolic phospholipase A2 (through activation of lipocortin-1 (annexin)) which controls the biosynthesis of pro-inflammatory prostaglandins and leukotrienes.|
|Clinical Trial ID||Title||Type||Source||Comment||References|
|NCT03158311||Study to Compare QVM149 and Free Triple Combination of Salmeterol/Fluticasone + Tiotropium||Phase 3 Interventional||Novartis||Based on results from this trial, this combination therapy is under regulatory review in multiple countries to gain clinical approval.||1|
For extended ADME data see the following:
Electronic Medicines Compendium (eMC)