dacarbazine   Click here for help

GtoPdb Ligand ID: 9075

Synonyms: DTIC-Dome®
Approved drug
dacarbazine is an approved drug (FDA (1975))
Compound class: Synthetic organic
Comment: Dacarbazine is a triazine DNA alkylating agent.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 7
Hydrogen bond donors 2
Rotatable bonds 3
Topological polar surface area 95.44
Molecular weight 182.09
XLogP -1.56
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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Canonical SMILES CN(NN=C1N=CN=C1C(=O)N)C
Isomeric SMILES CN(N/N=C\1/N=CN=C1C(=O)N)C
InChI InChI=1S/C6H10N6O/c1-12(2)11-10-6-4(5(7)13)8-3-9-6/h3,11H,1-2H3,(H2,7,13)/b10-6+
InChI Key OMJKFYKNWZZKTK-UXBLZVDNSA-N
No information available.
Summary of Clinical Use Click here for help
Dacarbazine is useful for the treatment of malignant melanoma and Hodgkin's disease.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
Dacarbazine alkylates and cross-links DNA, resulting in disruption of DNA function, cell cycle arrest, and apoptosis.
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