benperidol   Click here for help

GtoPdb Ligand ID: 9215

Synonyms: Anquil® | MCN-JR-4584 | R-4584
Approved drug
benperidol is an approved drug (UK (2006))
Compound class: Synthetic organic
Comment: Benperidol is a butyrophenone antipsychotic, with general properties similar to those of haloperidol.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 6
Topological polar surface area 58.1
Molecular weight 381.19
XLogP 3.04
No. Lipinski's rules broken 0
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Canonical SMILES Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2
Isomeric SMILES Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2
InChI InChI=1S/C22H24FN3O2/c23-17-9-7-16(8-10-17)21(27)6-3-13-25-14-11-18(12-15-25)26-20-5-2-1-4-19(20)24-22(26)28/h1-2,4-5,7-10,18H,3,6,11-15H2,(H,24,28)
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Summary of Clinical Use Click here for help
Usually prescribed to manage antisocial hypersexual behaviour caused by mental illness.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
Principal molecular mechanism of action is as a dopamine receptor antagonist.
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