CDP840   Click here for help

GtoPdb Ligand ID: 9330

Synonyms: CDP 840 | CDP-840
Immunopharmacology Ligand
Compound class: Synthetic organic
Comment: CPD840 is a potent, competitive, orally active, and selective inhibitor of all four PDE4 isoenzymes [3]. It was developed primarily for potential anti-inflammatory effects in asthma and chronic obstructive pulmonary disease (COPD) [2]. The compound is now available for repurposing via the MRC-Industry Asset Sharing Initiative 2016 (full compound list).
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 1
Hydrogen bond donors 0
Rotatable bonds 7
Topological polar surface area 31.35
Molecular weight 373.2
XLogP 5.43
No. Lipinski's rules broken 1
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Canonical SMILES COc1ccc(cc1OC1CCCC1)C(c1ccccc1)Cc1ccncc1
Isomeric SMILES COc1ccc(cc1OC1CCCC1)[C@@H](c1ccccc1)Cc1ccncc1
InChI InChI=1S/C25H27NO2/c1-27-24-12-11-21(18-25(24)28-22-9-5-6-10-22)23(20-7-3-2-4-8-20)17-19-13-15-26-16-14-19/h2-4,7-8,11-16,18,22-23H,5-6,9-10,17H2,1H3/t23-/m1/s1
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Mechanism Of Action and Pharmacodynamic Effects Click here for help
Cyclic-AMP-specific isoenzyme phosphodiesterase 4 (PDE4) is the predominant PDE found in proinflammatory cells. Inhibition of the PDE4 in these cells effectively elevates the intracellular cAMP levels, which in turn inhibits release of inflammatory mediators. This action dampens the inflammatory response, which is expected to translate to clinical benefit in inflammatory diseases such as asthma and COPD.