CDP840   Click here for help

GtoPdb Ligand ID: 9330

Synonyms: CDP 840 | CDP-840
Immunopharmacology Ligand
Compound class: Synthetic organic
Comment: CPD840 is a potent, competitive, orally active, and selective inhibitor of all four PDE4 isoenzymes [3]. It was developed primarily for potential anti-inflammatory effects in asthma and chronic obstructive pulmonary disease (COPD) [2]. The compound is now available for repurposing via the MRC-Industry Asset Sharing Initiative 2016 (full compound list).
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 1
Hydrogen bond donors 0
Rotatable bonds 7
Topological polar surface area 31.35
Molecular weight 373.2
XLogP 5.43
No. Lipinski's rules broken 1
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES COc1ccc(cc1OC1CCCC1)C(c1ccccc1)Cc1ccncc1
Isomeric SMILES COc1ccc(cc1OC1CCCC1)[C@@H](c1ccccc1)Cc1ccncc1
InChI InChI=1S/C25H27NO2/c1-27-24-12-11-21(18-25(24)28-22-9-5-6-10-22)23(20-7-3-2-4-8-20)17-19-13-15-26-16-14-19/h2-4,7-8,11-16,18,22-23H,5-6,9-10,17H2,1H3/t23-/m1/s1
InChI Key UTUUPXBCDMQYRR-HSZRJFAPSA-N
No information available.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
Cyclic-AMP-specific isoenzyme phosphodiesterase 4 (PDE4) is the predominant PDE found in proinflammatory cells. Inhibition of the PDE4 in these cells effectively elevates the intracellular cAMP levels, which in turn inhibits release of inflammatory mediators. This action dampens the inflammatory response, which is expected to translate to clinical benefit in inflammatory diseases such as asthma and COPD.