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Synonyms: CDP 840 | CDP-840
Compound class: Synthetic organic
Comment: CPD840 is a potent, competitive, orally active, and selective inhibitor of all four PDE4 isoenzymes . It was developed primarily for potential anti-inflammatory effects in asthma and chronic obstructive pulmonary disease (COPD) . The compound is now available for repurposing via the MRC-Industry Asset Sharing Initiative 2016 (full compound list).
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
|No information available.
|Mechanism Of Action and Pharmacodynamic Effects
|Cyclic-AMP-specific isoenzyme phosphodiesterase 4 (PDE4) is the predominant PDE found in proinflammatory cells. Inhibition of the PDE4 in these cells effectively elevates the intracellular cAMP levels, which in turn inhibits release of inflammatory mediators. This action dampens the inflammatory response, which is expected to translate to clinical benefit in inflammatory diseases such as asthma and COPD.