dopamine   Click here for help

GtoPdb Ligand ID: 940

Synonyms: 3-hydroxytyramine
Approved drug PDB Ligand Immunopharmacology Ligand
dopamine is an approved drug (FDA (1974))
Comment: Dopamine is the precursor to norepinephrine (noradrenaline) and epinephrine ((±)-adrenaline).
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 1
Hydrogen bond donors 3
Rotatable bonds 2
Topological polar surface area 66.48
Molecular weight 153.08
XLogP 0.65
No. Lipinski's rules broken 0
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Canonical SMILES NCCc1ccc(c(c1)O)O
Isomeric SMILES NCCc1ccc(c(c1)O)O
InChI InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2
No information available.
Summary of Clinical Use Click here for help
Used clinically to correct hemodynamic imbalances present in shock syndrome due to myocardial infarction, endotoxic septicemia, renal failure, open heart surgery and chronic cardiac decompensation.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
Dopamine-induced activation of β-adrenoceptors and release of norepinephrine from sympathetic nerve endings causes positive chronotropic and inotropic effects on the myocardium, which include increased heart rate and cardiac contractility.