dopamine   Click here for help

GtoPdb Ligand ID: 940

Synonyms: 3-hydroxytyramine
Approved drug PDB Ligand Immunopharmacology Ligand
dopamine is an approved drug (FDA (1974))
Comment: Dopamine is the precursor to norepinephrine (noradrenaline) and epinephrine ((±)-adrenaline).
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 1
Hydrogen bond donors 3
Rotatable bonds 2
Topological polar surface area 66.48
Molecular weight 153.08
XLogP 0.65
No. Lipinski's rules broken 0
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Canonical SMILES NCCc1ccc(c(c1)O)O
Isomeric SMILES NCCc1ccc(c(c1)O)O
InChI InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2
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Lack of discrimination by agonists for D2 and D3 dopamine receptors.
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Expression and pharmacological characterization of the human D3 dopamine receptor.
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Selective substrates for non-neuronal monoamine transporters.
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A functional test identifies dopamine agonists selective for D3versus D2receptors.
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Nonconserved residues in the second transmembrane-spanning domain of the D(4) dopamine receptor are molecular determinants of D(4)-selective pharmacology.
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Suppression of neuroinflammation by astrocytic dopamine D2 receptors via αB-crystallin.
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Molecular cloning and characterization of a novel dopamine receptor (D3) as a target for neuroleptics.
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Cloning of the gene for a human dopamine D5 receptor with higher affinity for dopamine than D1.
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12. Tiberi M, Caron MG. (1994)
High agonist-independent activity is a distinguishing feature of the dopamine D1B receptor subtype.
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Cloning of the gene for a human dopamine D4 receptor with high affinity for the antipsychotic clozapine.
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Dopamine controls systemic inflammation through inhibition of NLRP3 inflammasome.
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16. Zhang Y, Jiang X, Qin C, Cuevas S, Jose PA, Armando I. (2016)
Dopamine D2 receptors' effects on renal inflammation are mediated by regulation of PP2A function.
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Interaction of organic cation transporter 3 (SLC22A3) and amphetamine.
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