esflurbiprofen   Click here for help

GtoPdb Ligand ID: 9420

Synonyms: (S)-flurbiprofen | BTS-24332 | SFPP | TT-063
Approved drug PDB Ligand Immunopharmacology Ligand
esflurbiprofen is an approved drug (PMDA Japan (2015))
Compound class: Synthetic organic
Comment: Esflurbiprofen is a topically applied, non-steroidal anti inflammatory drug (NSAID). It is the more active enantiomer of racemic flurbiprofen.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 2
Hydrogen bond donors 1
Rotatable bonds 3
Topological polar surface area 37.3
Molecular weight 244.09
XLogP 3.76
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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Canonical SMILES OC(=O)C(c1ccc(c(c1)F)c1ccccc1)C
Isomeric SMILES OC(=O)[C@H](c1ccc(c(c1)F)c1ccccc1)C
InChI InChI=1S/C15H13FO2/c1-10(15(17)18)12-7-8-13(14(16)9-12)11-5-3-2-4-6-11/h2-10H,1H3,(H,17,18)/t10-/m0/s1
InChI Key SYTBZMRGLBWNTM-JTQLQIEISA-N
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Summary of Clinical Use Click here for help
Approved in Japan; indicated for the relief of inflammation and pain associated with osteoarthritis. Clinicaltrials.gov list Phase 2 trial NCT02729207 which is evaluating esflurbiprofen in hydrogel patch form for local analgesia in ankle sprains.
Clinical Trials
Clinical Trial ID Title Type Source Comment References
NCT02729207 Proof-of-concept Study of NSAID Hydrogel Patch in Treatment of Acute Pain Phase 2 Interventional Teikoku Seiyaku Co., Ltd.